Optofluidic Device for High Resolution Volume Refractive Index Measurement of Single Cell
نویسندگان
چکیده
This paper reports a label-free biosensor combining microfluidics and optical detection based on a Fabry-Perot refractometer. The device monolithically integrates waveguides coupled to distributed Bragg mirrors and also a hydrodynamic particle injector enabling cells to enter the sensor cavity. Recent developments in sub-populations identification based on volumetric refractive index measurements of single glass beads are discussed. A statistically significant difference between two sub-populations of glass beads was found when particles flow through the detection region.
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تاریخ انتشار 2012